报告题目（1）： Using proteomics and transcriptomics to understand the interaction between human respiratory syncytial virus and the host cell - a constant battle

　　报 告 人：Dr. Julian A. Hiscox (英国Leeds大学)

　　报告时间：7月25日上午9:00-10:00

　　报告地点：生命学院四楼多媒体室

　　报告内容简介：

　　This talk will focus on human respiratory syncytial virus - a major paediatric and adult respiratory infection. The lecture will briefly cover the proteomics and transcriptomics aspect for data mining and then focus on how we have shown that mitochondria act as sentinels of infection to co-ordinate the innate immune response against this virus and how the virus destroys mitochondria and activates the cell cycle to increase progeny virus production.
The work presented is based upon our initial studies published in Munday et al. 2010 Molecular and Cellular Proteomics (v9 p2438-2459), Munday et al. 2010 Proteomics (v10, 4320-4334) and just coming out in J.Virol. Wu et al. 2011. The work on the mitochondria as sentinels of infection has been submitted to J.Virol. but is unpublished and really novel.

　　报告题目（2）： Methods talk: “ Using stable isotope labeling and bioinformatics to integrate proteomes and interactomes in virus infected cells”

　　报 告 人：Dr. Julian A. Hiscox (英国Leeds大学)

　　报告时间：7月26日上午9:00-10:00

　　报告地点：生命学院四楼多媒体室

　　报告内容简介：

　　This talk details how stable isotope labelling can be used in conjunction with LC-MS/MS to study the interactions of viruses with the host cell at the global level and also how host cell processes can be studied (not just infected ones). It also focuses on using this methodology to generate protein:protein interactome maps. The talk will cover both successes and failures in the lab using this methodology and what we have learnt along the way. More importantly perhaps it shows how bioinformatics is important followed by functional analysis and validation. Mostly in this talk I’ll use examples taken from our published work on infectious bronchitis virus, and unpublished work on influenza virus, porcine reproductive and respiratory syndrome virus, crimean congo hemorrhagic fever virus and human respiratory syncytial virus.

　　报告人简介：

　　Julian A. Hiscox博士，英国利兹大学（University of Leeds）Reader。多年来从事RNA病毒，包括冠状病毒、呼吸道合胞病毒、猪繁殖与呼吸综合征病毒等研究，在病毒与宿主相互关系，病毒与细胞周期的研究中取得了丰硕的成果。近两年来利用蛋白组学的方法研究病毒感染的宿主细胞，取得了很大的进展。Hiscox博士已经在Mol. Cell. Proteomics，Cell Microbiol., J. Virol., Cell cycle等杂志上以第一作者或通讯作者身份发表三十几篇科研论文，并在Nat. Rev. Microbiol. 和EMBO Rep.等著名学术刊物上发表了多篇综述性文章。

　　欢迎广大师生光临！

　　　　　　　　　　　　　　　　　　　　　　　　　　　　　生命科学学院
　　　　　　　　　　　　　　　　　　　　　　　　　　　　　2011年7月16日